The Legend of Zelda: Twilight Princess

The whole fight is pretty amazing sound-wise, but the best parts are when Morpheel starts swimming around the room (starting around 2:14). The player’s goal is to latch onto him with the Hookshot, and stab his weak point. Every time the player does so, it plays a tune that tells the player ‘Now is your chance!’. The music, along with the sound effects of the stabbing and the screaming of the beast while doing so, makes for a great boss fight.